So, what does CBD do to the Brain? The brain is a fascinating part of the body. The chemicals inside of it influence every part of our lives and our days. When we add new things to our body it changes our perceptions, how we see the world and how we act. The CBD effects on our body, especially when we take CBD consistently, are significant, but CBD effects on the brain are also key. Whether that is changing hormones produced, blood flow and dopamine exploring CBD’s effects on the brain is important before you start your CBD and CBD oil journey. So let’s dive into it, so get on your finest lab goggles.

What does CBD do to the Brain?  

Let’s examine the neural pathways and answer the question “what does CBD do to the brain”? CBD, or cannabidiol, is a chemical compound from the Cannabis sativa plant. Unlike THC, its psychoactive cousin, CBD doesn’t make you high. It does, however, offer a wide array of roles. Preliminary studies suggest CBD’s long term brain effects can be enormous. Taking MightyMe every day can grow, change and adjust the way our brain chemistry works. Another FAQ brought up is, how long does CBD affect the brain for? The answer to this is that it varies significantly person to person, dosage and quality. 

What is the Endocannabinoid System?  

The brain is an incredibly complex beast, but in its vast ocean of chemicals and nerves, there’s a leviathan hiding inside known as the endocannabinoid system (ECS). This intricate network is woven through your body and brain and includes receptors, enzymes, and endocannabinoids. Think of it as the grand regulatory symphony orchestrating homeostasis, ensuring that various systems like mood, sleep, pain, and appetite are in harmony. The ECS has two primary receptors – CB1, mainly found in the brain, and CB2, common in the immune system. The ECS is like the almighty helmsman, steering the ship that is our body.

How Does CBD Impact the Endocannabinoid System?  

Let’s dive into the question of “how does CBD work in the brain?” and how it interactions with the Endocannabinoid System (ECS). CBD is somewhat mysterious because, unlike THC, it doesn’t directly bind to CB1 or CB2 receptors. Instead, it modifies their ability to bind to cannabinoids. Moreover, CBD inhibits the FAAH enzyme, responsible for breaking down anandamide, an endocannabinoid that modulates pain and mood. Therefore, taking CBD ensures that more anandamide is available to the body.

What are the Scientific Ways CBD Affects the Brain?  

CBD’s effects on the brain are significant. Through its interaction with the 5-HT1A receptor, CBD can impact serotonin levels, a part of the brain that is tied to how certain antidepressants work. Its engagement with TRPV1 receptors is thought to be responsible for its role in pain modulation. In cases of epilepsy, CBD’s anticonvulsant properties come into play by dampening the excessive neuronal activity. Moreover, it’s also involved in the regulation of CBD dopamine and can affect how we perceive rewards and pleasure. 

What are CBD’s long term brain effects? 

CBD long term brain effects are still under the microscope, but some studies suggest it may potentially have a role in anxiety and pain. However, the longer you take CBD, the more likely it works with your neurotransmitters and CBD dopamine receptors. But you should not, it’s important to note that research is ongoing, and new discoveries into CBD effects are made every day.  

What are the CBD’s negative effects on the brain? 

As above, the CBD effects on the brain are being researched and explored everyday. Most of the negative effects studied so far are related to THC, the compound that makes you high. There are always those stereotypes of stoners but its important to remember just how different CBD is to THC. CBD’s effects are very different, and though it can have mild side effects like dizziness and drowsiness, there aren’t many studies that point to negative long term CBD effects on the brain. 


It is evident that CBD, CBD oil and its effects on the brain are rather intricate. The way that CBD works with the ECS is significant, changing CBD dopamine levels and the way your neurotransmitters work. However, the long term CBD effects on the brain still require a lot more research but may well suggest a life of boosted balance.